BIOLOGY 190

CHAPTER 8
AN INTRODUCTION TO METABOLISM

OBJECTIVES

1. Distinguish between kinetic and potential energy.*
2. Explain, in your own words, the First and Second Laws of Thermodynamics.*
3. Explain the role of catabolic and anabolic pathways in cellular metabolism.*
4. Describe the energy profile of a chemical reaction including activation energy (E_A) and chnage in free energy (delta G).*
5. Define equilibrium for a chemical reaction and its free energy value.*
6. Describe the relationship between chemical disequilibrium and life. *
7. Describe the function of ATP in the cell.*
8. List the three components of ATP and identify the major class of macromolecules to which it belongs.
9. Explain how ATP performs cellular work and is involved in coupled reactions.*
10. Describe why ATP is so unstable.*
11. Describe the function of enzymes in biological systems.*
12. Explain the induced fit model of enzyme function and describe the catalytic cycle of an enzyme.*
13. Explain how enzymes effect the energy profile of a reaction*
14. Understand important terms, such as substrate, active site, induced fit.*
15. Explain how enzyme activity can be modified by temperature, pH, and inhibitors.*
16. Compare and contrast competitive and noncompetitive inhibitors.*
17. Define allosteric inhibitors.*
18. Define feedback inhibition.*

KEY TERMS
metabolism, catabolic and anabolic pathways , spontaneous reaction, free energy, exergonic, endergonic, equilibrium, catalyst, enzyme, activation energy, transition state, substrate, active site, induced fit, competitive inhibitors, noncompetitive inhibitors, allosteric inhibitors, feedback inhibition.